I honestly couldn’t decide so I voted 243 Win since that’s what I killed my last deer with. The great thing about whitetails is that nearly any weapon will work! I’ve shot them with 22lr, 22wmr, 223 REM, 243 Win, 7/08 Rem, 7RM, 30/30, 308 Win, 300WSM, 300WM, 338/06, 338WM, 12ga, 50cal MZ, and arrows.
Honestly, which gun to take has always been part of the fun’s over the years. And before anyone wonders about the smaller cartridges, yes it was legal and they were close range head shots. And devastating results. As a younger hunter, I though there was no such thing as overkill. Now I like challenge over success. To each there own!