No visible reaction? As in, they completely ignored the shot and kept on feeding or whatever they were previously doin?I know a guy that started hunting with a .22-250 using 52gr HP after shoulder surgery.
Did it kill deer? Yes. Did we find all of them? No, with no visible reaction to the shot and no blood trail several were not found until days or weeks later as they traveled 100 to 200 yards after they were hit with no way to track them.