Part of the issue with failures, whether a 22 cal or 338 cal is that the animal isn’t found. It’s more rare to recover a failure because usually it requires a follow up shot on a running animal that’s trying to get the heck out of town.
Last year I shot a big buck with a 180 eldm. I saw and heard impact and his front leg was hanging. I panicked, missed a couple of fast walking follow up shots and the deer was never seen again. No blood, no deer. It could have been a low shot, hit leg and brisket, or lower, or it could have hit shoulder and failed to penetrate adequately. I’ll never know, but always wonder!