I'll say yes and no.Ok so for someone who is a legitimate novice and hasn’t shot enough to know any better…
When I started shooting I quickly found that I was fairly recoil sensitive. Fast forward a couple seasons and a significant amount of practice PLUS a suppressor.
I bought a Savage 300WSM Ultralite and honestly even without hearing pro on I don’t flinch when it goes off. The recoil doesn’t bother me. I have no question I could shoot 5x more rounds at the range with a suppressed 6CM, but I think I’m fairly GTG out to 400 yards.
Does all of this hoopla on Rokslide (which cartridge you shoot, which scope you use) matter all that much if you likely won’t shoot past 400-500 yards?
It's a lot more fun to shoot a lot (suppressed or not) with the smaller cartridges. And you will shoot a .223 more in practice than a 300 of any flavor.
In hunting situations I always remember the first year hunting suppressed with my daughter (my girls hunt with a .223) . She told me numerous times how much easier/more comfortable she was behind the rifle knowing that the suppressor was there.....confidence!
Translate that to you or me (I've run 1000+ rounds thru rem mags and win mags in the last few years and even more in .223 and various 6.5s) and any rifle that you shoot a lot and are very comfortable behind will do the work. Again, the smaller ones are just more fun at all ranges.
Most of my hunting in the last few years has been with a (couple of) 6.5 CMs, .223 or 6.5 SAUM because I shoot them the most and am 100% confident in them. The big 300s and 7mm's haven't shown me enough of an edge in performance to make them worth the extra blast/recoil at the range or in the field.