I had 330K on my 2000 F350 when I retired it. One of the most important things you can do if you tow is to upgrade the transmission cooler. The stock one is laughably small. Also, add gauges so you can monitor the trans temp! I used a ford trans cooler out of a newer (2008ish) truck that was 28 row instead of the little 7 or 9 row that was in them from the factory. It was basically a bolt in swap with a few plumbing fittings required also. with the exception of replacing glow plugs at around 250K and a valve cover gasket due to an electrical failure at the plug I was never inside the engine, transmission or the turbo.
I have some regret for having sold it but the bottom line was that I owned that truck for 12 years, put well over 200,000 miles on it and sold it for exactly what I paid for it.
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