First go to that spot on a scouting trip where you'll go in when it's daylight already, and leave while it's still daylight. This way you get an opportunity to learn and imprint into your memory the layout of the land and make note of landmarks within it. Also you can potentially mark certain trees with reflective thumbs tack if there is a turn you're likely to miss while exiting in the dark. Such as a detour ya gotta do when conditions change and there is higher water level in a creek or something and you can't cross where you normally would.
When hunting solo, take a screenshot of the satellite view of the map of where you intend to go. Annotate that screenshot showing what will be your route of travel you intend to take to get in there and where you intend to stop and hunt at.
The person you give/email all this info to... you need to explain to them your general game plan in terms of how long you intend to stay in there. Even if it's just a day hunt. If you think you *may* end up deciding to remain in there longer, you have to express all that to the homefront contact person.
You also need to call or TXT them when you're "down back outta the mountains, and heading home" so they know you're back outta there and safe and everything is cool.
DON'T STRAY FROM THE GAMEPLAN YOU SHARE WITH THEM! You are sharing this info with them so that if you get knocked unconscious, have a heart attack, stroke, whatever... and they don't hear anything from you after the predetermined amount of time you told them you planned to leave by? They're instructions are to call the appropriate ranger stations or authorities so they can start looking for you and have an idea of where your general whereabouts should be. You don't wanna be a "needle in a haystack" when it's time for Search and Rescue to come find you. You need them to find you QUICKLY.
Since you're going in alone. Err on the side of caution and bringing too much stuff in with you, rather than not enough. At worst, it's helping to build up your strength for that moment-of-truth when ya gotta packout an animal. And if ya had to, you could always leave some stuff stashed out there and come back to get it later if you have to shave some weight for hauling meat.
Bring meds to address any and all reasonable problems you can imagine. Immodium. Acid blockers. NSAIDS. Allergy EyeDrops are a biggy too. Meds to help with breathing if that applies to you. Baby sunscreen in the stick-deodorant-style format. Don't forget to do your nose and ears! Allergy meds like Zrytec or similar. (Allergy meds can also help calm down the redness/reaction if you get poked by the wrong kind of painful stinging plants, or insects). And for meds? Shy away from taking any GelCaps format medicine, or capsule type of medicine (if you can help it) sometimes the heat will cause them to melt and be difficult to retrieve cause they're all stuck to everything else.
Another piece of advice that I highly suggest you take heed to? Make sure you load your pack in a nice and relaxed fashion at least a day beforehand. You DO NOT want to be in a rush loading your pack at 2am or 3am, otherwise you'll mess up and forget something, and usually it'll be the thing you'll wish you had on that outing!
For loading and unloading your pack with your essentials... I use a plastic container in my garage that I put all the regular non-food gear items into. So I've just got 1 place to look for them. So I can stare and snoop around just in that 1 place and I know it should be in there. And..since all these things are in 1 place.. you'll end up seeing something else you forgot about thinking to take with you, but now realize would be good to have on this particular hunt since you're looking at it.
If ever you step away from your pack, for more than just "using the bathroom", make sure to bring headlamp, and ALWAYS ALWAYS have some kind of weapon on your person. Not only to defend with, but you never know when you're going to see that game animal while you're out there!
Split your water into at least two separate containers within your pack. That way, if you haven't been very good about conserving your water and you run out on your main drinking bladder... you'll realize oh shoot, I can't go any deeper into the woods than this, and I must turn around now. Also... if one of the containers fails and leaks.. that way you're not totally screwed and without water now. Running out of water can be VERY SCARY! Especially if upon leaving you have to go uphill and it's steep.
If it's new territory for you.. make damn well sure you've taken extra time to note the landmarks around where your pack is at, should you step away from it. You'd be surprised how much that camo on the pack can make you at first not see it if you went any significant distance away from your pack.
Cover your cooler. If it's locked into the pickup bed with a cable, cover it with a cheap Walmart throw blanket. Extends the duration it remains cold since suns rays aren't falling directly on it. If it's inside your vehicle, cover it with an inexpensive regular ol thick Coleman sleeping bag that's unzipped. And crack two windows just a tiny bit so the hot air from the sun heating up your car can escape, so it's not super hot inside the car. Again, extends the amount of time it all remains cold in the big cooler.