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Not a brown bear or a TMK, but Harry Caldwell shot a lot of tigers in China with a 22 Hi Power. Its been several years since I read his book, so I did a little google research to refresh my memory. He went to China in the early 1900’s as a missionary, and found out someone needed to deal with man eating tigers. His brother sent him a rifle, IIRC a 303 savage, but he mailed it back and specifically requested a 22 hi power.
Bear in mind, Harry was hunting known man eaters, often at night, and that was his choice of weapon. I found a couple sources online that said he killed 48 tigers during his time there, not sure how many with the 22. It’s been a while since Iv’e read it, and I know he shot some with a 303 and a shotgun also. The book is called Blue Tiger if anyone’s interested.