I have that exact pistol, the 22/45 Lite. I paired it with a small Burris red dot and LOVE it. I can easily take squirrels and grouse with it and I strongly prefer it over a shotgun now - no more worry about missing a pellet. It's also extremely light, so it's really pleasant to carry almost anywhere, and I believe it's a great pistol to teach a new shooter (like my kids) about better trigger-control with pistols, because there's almost no recoil so you don't learn flinching instincts.
My only complaint (if you could call it that) is that it definitely requires good ammo to cycle properly. It runs about every 40gr round I have reliably, and I have probably all of the brands because I'll buy literally any brand of .22 if it's on sale, no matter who makes it. It does NOT seem to like subsonics and lighter rounds, like CCI Sub-Sonics, Quiet-22, 21gr CCI Coppers, and even 30gr stuff. I was kind of hoping I could make it a "quiet companion" type of pistol, something I could use on grouse in elk season without overly pressuring the elk, but I'm sticking with full power rounds for now.
I see others have had better luck with those rounds and this pistol - maybe mine just has a personality? But mine will stovepipe (and even crimp a round occasionally) or just straight up not cycle. YMMV.