Yes, but I think only to a certain point. I never tried single bevels heads with my 425 grain builds. I think my FOC at that time was 11-12%. I thought I had built the perfect hunting arrow and several buddies followed along.Do you think you'd have the same luck with a 450 grain COC single bevel as the Slick Trick that has 4b chisel tip and four blades? Seems like a small increase from 400 gr to 450 gr (12.5%), a little more FOC (12-18%) and a super sharp COC head would address the penetration issue.
The photo below is just one example of my frustration and by no means the only example. This Antelope was broadside on video when I shot. I had no time to use a rangefinder and I was happy with the shot and point of impact given the conditions. Not perfect but to me it looked good enough. As he turned to run I realize I could see 2/3 the shaft sticking out. At about 200 yards the arrow fell out and he continued on for another 200 yards or so before lying down. Video kept rolling and we kept watching. After several hours I was pissed, because this was not the first time I had seen this same result. I finally snuck up to the big pine tree behind him and made a second shot. The second arrow never made it through from the other side either. I think on this antelope your suggested arrow would have surely helped and would have increase penetration.