Heresy, maybe, but the only load I've ever hunted with is Hornady American Whitetail with 150gr Interlocks. I got a stupid deal on a bunch when the local Dick's dropped their FFL side. Probably have another two-three years worth of practice and hunting before I start looking again. Only deer that has gone more than a few dozen yards was a doe I shot in the neck when she sat back and head-bobbed right as I pressed the trigger. Most have gone less than twenty.
Not the end-all be-all, but its got a 100% success rate for me in the Indiana deer woods with ranges from straight down to 160-ish yards. Would like to try something at 250ish, but that's hard to come by with a good backstop. Around my parts, anyway.