The advantage I see is that for shooting without dialing, a 300 yard zero keeps the bullet in vitals much further out than a 100 yard zero.
With a 100 yard zero, the bullet drops out of the vital zone much closer in and very quickly requires more than just a "hand width" of estimation.
I've used a 3" high @ 100 (280 yard zero) on my 308s and 30-06s for years. I have reticle dots for further shots, if needed, but for me, they very rarely are.
I guess I should add for the OP, I don't think what I'm doing for 0 - 325 or so yards is practical much further out. Reticle dots or hash marks you're pre-familiar with would be needed further out if you're not dialing, but I think that's what you're saying.