So, certainly not a failure story, but more of a "I need to manage my expectations" story...
This past weekend my daughter shot a medium sized mulie doe, impact MV around 2150. Got fragmentation and exit, entered 2-3" behind the crease of the shoulder and exited a couple inches in front of the diaphragm. Back half of one lung was destroyed, and moderate damage (probably a third) to the other. She ran probably 200-250 yards with very sparse blood trail that went away completely, and we only found her after several hours of grid search since she ran over a couple of finger ridges out of sight. I'm very glad I was able to see bullet impact and see the exit wound as she went over the ridge, as she showed very little sign of having been hit as she ran.
In the end, the bullet performed fine, did substantial damage, and I am sure if the shot was 2" further forward I would be singing the chorus of the "Praise be to the TMK and its father Sierra" song but the feeling in the gut when you think your 10 year old little girl may not recover her first deer is not a good one.
I don't think I'm claiming that another bullet or caliber would have done better in this specific instance, but I can't help but think I've shot deer and seen them shot in similar spots with various 30 cal interlocks, ELDs, 7mm ballistic tips, Bergers, etc and they have seemed to go down faster and leak a lot more blood with a 120-180 grain bullet that expands/fragments well. Every shot is different though, and maybe this was a 1 out of 10 that would have done this regardless of bullet, and this bullet would have produced similar results on all those others I've seen.