There is no reason you couldn't put the sawyer in-line with any bladder/hose set up. The only potential issue I see is how you are going to fill the (dirty) bladder. Even with the wide opening on the big zip we sometimes have trouble getting it to fill. It sounds funny until you try it, but you often have to do multiple "scoops" to get the bag full, particularly in smaller or shallower streams. Unless you have water pouring over a dam or down a waterfall, I could see it be a challenge to filli the bladder through the small camel back opening. Just something to consider...