Other casual observations:
1. "Health nut" in my experience has a high probability of just meaning "nut"...
2. Blood pressure meds are some, if not the, safest and most effective medications in existence. If my BP was genetically high (190/110, holy cripes) I'd be gobbling the BP meds.
3. Genetics are the end all. My grandmother smoked for over 40 year and lived to 85, basically completely healthy until the last couple months.
A person smoking for 40 years and not dying from it is not a proof point of anything. Even the popular add campaigns from several years back claimed "1 in 4 lifetime smokers die from it" meaning that 3 in 4 do not.
Out of curiosity, assuming your grandma did not take up smoking at 45 it sounds like she smoked from maybe 20 to 60? If true most of the risk would have been long gone long before she died.
Anyway I dont disagree that genetics are important but so it lots of other stuff, obesity kills a heck of a lot of people to claim that "genetics are the end all"