There’s an old guy in our family that died 10 years ago from a prion related thing of some kind - his only major risk factor was eating wild game, but who knows if he picked it up from blowing dirt coming off a livestock hauler, or drinking mountain water. At the time nobody knew what to think about it other than it’s really rare. Makes a guy think.
Anyway, this is a pretty good professional paper that gives a pretty broad overview of what’s known, what’s not known, and what direction research will likely be headed towards.
Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic Wasting Disease (CWD) is the prion disease with the highest spillover potential, ...
www.ncbi.nlm.nih.gov
Genetic research professional papers would be interesting to read if they weren’t so hard to follow - CWD isn’t just one thing - there are many different types and it is mutating - some strains are more likely to cause problems with some types of animals. What was true 20 years ago may not apply to new strains. Makes a guy think - hopefully things get sorted out.