Where does the shot placement have to be to kill an animal with a 300 Winchester Magnum, but not with a 6.5 PRC?
If the “bigger bullet going faster” makes a difference, that is the question you must answer. Can I take a 12-MOA shot instead of a 10-MOA or an 8-MOA shot because I have a bigger, faster bullet?
This is the kind of stuff my dad used to argue when he took the 9.3x74R out deer hunting. The 270-grain Speer bullets had very thin jackets and made devastating wounds at 2600 FPS. And he had a few marginal kills with it over the years. I remember a liver shot that bled out in under 100 yards. The deer was practically gutted and tripped over its own intestines. And a facing shot that missed the vitals but took out the right shoulder, all the ribs on the right side, shattered the femur, and cut the femoral artery. The bullet exited the animal. For all I know, it’s still going thirty-five years later.

Of course, we had to throw away half the deer. And neither of those shots would be considered “what a hunter should be trying to do.” He should not have taken either shot.
____________________
“Keep on keepin’ on…”