How much of a difference does a head stamp make?

For what you’re looking to do mixed will be fine. I wouldn’t be running up near max pressure though. Like other have said, if you want to eliminate one thing from the potential issues of developing a good load you’d want to run same brand and lot.
If you keep pressures low 200-300 piece of quality brass will last the life of the barrel of both the calibers you listed.
 
Another vote for you should be fine. Have I done it in the past? Heck yeah I have. Do I any more? Not at all. Best thing to do is test it! Load up three and three, send them at 500, see if you have a six shot group or two three shot groups.
 
Yea it’s gonna matter for your itty bitty groups way out there and tight sd/es.
It won’t matter much on a whitetail to a few hundred yards
 
0-500 yards Mix all the headstamps.. You won't notice a difference unless you're trying to have sub MOA groups. 1.5 MOA at 500 gives you a ~7" group at 500. Thats kill zone
 
To be clear, you are talking about basically making a batch of rounds (say 50) but with mixed brass???

I guess I think hand-loading is about consistency and by mixing brass consistency just goes out the window.

Will it matter? Maybe who knows unless you try it but…why try it? Just buy some good brass.
 
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