How much of a difference does a head stamp make?

For what you’re looking to do mixed will be fine. I wouldn’t be running up near max pressure though. Like other have said, if you want to eliminate one thing from the potential issues of developing a good load you’d want to run same brand and lot.
If you keep pressures low 200-300 piece of quality brass will last the life of the barrel of both the calibers you listed.
 
Another vote for you should be fine. Have I done it in the past? Heck yeah I have. Do I any more? Not at all. Best thing to do is test it! Load up three and three, send them at 500, see if you have a six shot group or two three shot groups.
 
Yea it’s gonna matter for your itty bitty groups way out there and tight sd/es.
It won’t matter much on a whitetail to a few hundred yards
 
0-500 yards Mix all the headstamps.. You won't notice a difference unless you're trying to have sub MOA groups. 1.5 MOA at 500 gives you a ~7" group at 500. Thats kill zone
 
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