At very close range I’d be wary. Small sample size here, but the only buck I’ve lost was due to Hornady white tail 100gr interlock in my .243. Shot a buck at 50 yards in the neck (poor shot) and knocked it, then it got up and took off. Found it 3 hours later just feeding away, a little trickle of blood running down its neck. Went for a shoulder shot to drop it (20yards) and made a solid hit, but it disappeared. Looked for a day and a half in thick brush. I’m guessing the bullet was going too fast for impact and broke apart on the shoulder?