In my experience there's a fair bit of variation in synthetic insulation. I'll loosely categorize into: 'active insulation' 'midlayer' and 'static insulation'. I have one in each genre.
The 'active' insulation is a replacement for a fleece for me. Mine (mammut rime light flex IN) has ~30gsm of synthetic fill and is body-mapped, some regions have no insulation, only a windshell, some grid fleece. This is a competitor for the 'polartec alpha'/'alpha-direct pieces a-la sitka ambient. I do intend to buy one of the 'alpha' fleeces for experimentation.
I midlayer pieces are potentially a replacement for high-pile fleece + windshell/softshell or for a lightweight down puffy (think 0.375" loft 'micropuff') Has the benefit of moisture tolerance if you sweat into it unlike down. Is usually one piece rather than two like a fleece+windshell.
~50-60gsm insulation. (mine is rab xenair light)
static insulation is a replacement for a down puffy coat you're looking for 80-120gsm depending on how warm. Mine is 100/120ish gsm (rab generator alpine) and is suitable as a static piece down to say 15-20F or so, I've pushed it down below 10F with some midlayers.
I've found the 'active insulation' piece to be handy for warmish transition temps 40-60F, september alpine mule deer. I pair it with a sun hoodie and it comes out when windy, still hunting, & static, otherwise running sun hoodie only. It provides a little insulation and a little wind protection but is still relatively breathable.
The 'midlayer' piece gets the least use for me in the woods. I would usually categorize it as an active piece for still hunting in cold temps. 20F to 40F. Think rifle elk at elevation, november whitetails etc. The face fabric is a little noisy & fragile for much of the still-hunting terrain though and so I frequently use a fleece + soft shell for these hunts instead, especially since they're usually truck hunts for me and weight is less of a concern.
the 'static insulation' jacket gets a lot of use for me because I live in western washington and so I'm often willing to pay a weight penalty for a little more weather resilience. Really great for static transitional cold temps (30F +/- 5) where you could have light rain/wet snow etc.