Here you go...there's a 356 bull bedded in the shade of the hill in the center of this photo:
Here's zoomed in with the camera I was carrying that day, he's 440 yards away.
I was carrying my 7 RM that day and 440 is within my shooting range, but if you notice in the first picture, there's a ridge in front of that bull, meaning I could get closer.
Rather than blast away at 440, which I'm sure I could have made that shot, I chose to get to the ridge in front of the bull.
The worst thing can happen if you try to get close is you blow the stalk, the bull could move, or something along those lines. The bull may get away, it may suck to work hard and not capitalize. Worse thing about shooting 4-5-6-7-1k hundred yards is you wound a bull that you never recover. Sucks for the hunter, and sucks even worse for the elk that has to die a slow death hours, days, or weeks later.
As it turns out I stalked that bull to about 50 yards, he sensed I was there and got up from his bed and started to move off. I took a knee and killed him with a single bullet at 55-60 yards...I like my odds wayyyyyyyy better at 55-60 yards than 440. Didn't have to worry about tracking a bull all over the place, didn't have to think about doping wind, didn't have to worry about spinning a turret, only had to worry about getting him back to the truck. I could have killed that bull with my 6mm, 243, 338, 7 RM, 7-08, 30-06, 300 win, 25/06...hell even my 22-250 just as easily, rifle set up meant nothing.
Lots of calibers, really most ANY caliber is fine when you're shooting sane distances. As range increases variables creep in, don't care how much you shoot or how much you think you "know" about your rifle, wind, etc...just a fact. I've shot 2 elk at what I consider long range, and they both worked just fine but I don't like to do it. Not that I don't know HOW to make it happen, just not my bag. Judging by the amount of shooting I hear each year, I'd suspect there's a lot more that shouldn't be shooting LR at elk.
Knowing when, and more importantly when NOT to shoot, at any range, is what makes the difference between packing dead elk and chasing wounded elk. I'd rather pack dead elk.
Rifle set-ups DO NOT make up for poor decision making or poor performance at long range...period.