I put together a 280AI in 2014 and used is for every hunt up until last year. Prior to the 280, I shot a 300RUM and a Remington 721 in 30.06.
I bought a Kimber Montana 30.06 in 2018, killed 4 animals that year, one shot DRT out to 408 yards. However, any shot after the first, vertical stringing was unacceptable. I ended up bedding the rifle, but there was zero improvement.
I ditched the pencil profile barrel and had pac-nor screw a 6.5x55se, #2 profile barrel onto it last year. It's a tack driver with minimal load development. I use it for everything smaller than elk. So far, so good. 127LRX @ 2800fps (iirc) has done the job out to 330 yards. My dad only shoots one rifle, a weatherby mark v in 30-378. He doesn't believe in small calibers!