You're getting great comments here. There's nothing wrong with working up a load that shoots great for you, and going hunting. As long as you keep your shots where you don't need to dial elevation much.. and of course you should always practice at your personal maximum range for hunting.
As you get past 200, 300 yd depending on your cartridge, everything really matters. You can make your own dope chart my actually shooting. But if you want to take a ballistics table, put in all the variables, dial the scope and make a good shot I can tell you factory ammunition rarely makes the velocity they publish. Some does, much doesn't.
When I'm reloading, I watch extreme spread and standard deviation with the chronograph. I have gotten some excellent groups at 100 yards with ammunition that has large extreme spread, but I don't think you'll do that at 400 or 500 yards. The math says you won't. Now, if my ES or SD is bad I keep working on the load because I know it won't work for me at longer ranges.
I shoot out past 500 yd pretty frequently and that's not even long range to a lot of people. But I shoot most of my deer at 35 yards here in the southeast.