Good topic, and can never be discussed too often, IMO, with the many archers getting in to elk hunting.
While I have had limited experience on elk (3 hunts in the last 4 years) I have had shots on bulls during each of those hunts and my partners have also been 100% on shot opportunities as well.
I am 2/3 on elk with shots at 36 (missed high), 35 double lung, and 14 hard quartering away in the boiler. One partner had a hard quartering away at 8 yards and the other passed on a cow inside 18 yards.
My site set up is a SpottHawg 5 pin set @ 20,30,40,50,60 in green, green, red (40), green, green. The 20 and 30 pins are a bigger dia than the red 40 and the 50 and 60 are smaller yet than the red 40.
I routinely practice at 70 yards which makes 50 and even 60 yard shots very comfortable for me. I would have zero issue shooting at 50 and if conditions warranted it, I would feel confident at 60 on a live target with my set up.