Evan makes several great points and I agree 100%!
I don't need to shoot very far on my first arrow, BUT, if things go wrong on the initial shot and I need a follow up arrow, than all bets are off and I will drop one in him at any distance. My bow 80 is sighted in out to 120 and I will use it when needed.
My antelope hunt this year is a good example. My first shot was at 47, but he spun and I caught guts and 1 lung. He ran out to 97 and stopped, so I dialed my 80 to 97 and dropped on in his lungs to put him down quickly.
I wouldn't shoot an animal at 97 on the first arrow, but I was glad I had the option.