1. 109s are gonna shoot best 2920-2940 with H4350, it's not hot, but I'd say it's medium warm psi levels, prob around 58-60k psi. Alpha ocd 6gt brass is very tough. I run 112s in my 24" short freebore chamber at 2910, and I was able to go all the way up to 3k fps before I found psi signs in case head, still no bolt lift.
For the long bearing 109eld, get the 170fb chamber, jump them 55k of so, I've found all eldm like to be 10k off, or back at 50-60k. They are more forgiving back at 55k, but not quite as precise, but they stay tuned there longer. If you have access to rl16, it will give you more velocity and lower pressure, however at the expense of quicker carbon buildup, especially in a suppressed barrel.
I have quite a bit of experience with the 6gt in comp/match settings, but have only killed game with my 22gt. I plan to run the 112s in the 6gt and 109 eldm in the 6cm this fall and put these bullets into game and see what they do. I was very pleased with the 108eh Berger performance last year from the 6cm at 3050mv.
2. I have a Tikka 6gt barrel that was on the womans rifle a few years back, but it was ran via aics mags, so no input there. I think it'd take a lil tuning honestly to get it 100% reliable. However from the M mags, it would do better than M+ as they are shorter.