Rl 25 with the 156 Berger has worked well for me out of a Christensen Mesa and 2 Seekins PH2's. Around 2975 fps with 59 grains charge weight. One of the Seekins prefers 58.4 grains at 2927 fps. They've killed elk, mulies, rockchucks, and antelope from up close to way out there. Unfortunately, it's getting just about impossible to get RL powders, and probably will be for quite a while. I'm going to re-do load development with N565 and H1000 soon so that I don't have to worry about getting RL25. If you have a good supply, go for it. If not, get some N565 and/or H1000 and go from there. The 156 is a great bullet that kills quick and is fairly simple to tune to your rifle.