The likelihood of a pass-through is more dependent on the bullet used than the cartridge that it comes from.
Use a bonded or mono-metal bullet and you will get a smaller wound channel and a higher probability of a pass-through.
Use a more frangible bullet and the wound channel will be larger and the probability of a pass-though will be less.
For me, I care about killing in the fastest way possible, which is why I have switched to the 123 grain SST and 120 Grain A-max in my Grendels. I was shooting 105 grain Cavity Backs.
Something that is often overlooked in these types of discussions is that when shooting a smaller cartridge, suppressed, is that I can spot my shots, hear the impact, and hear the deer running and crashing, if they happen to run out of sight. I have found I don’t need a blood trail because I know right where to find them as I heard them crash.
Had that happen on a Whitetail and a large hog in middle GA. Both shot with a 7TCU using 120 grain NBTs. No exit on either. Deer went 10 yards into the thick stuff, but I heard him pile up so I was able to walk right up to him. Hog went a bit further, but again, I heard him run and crash, so I had a very good idea of which direction he went, and the general area he was in. The guide and I were able to crawl through the tangle, and when I said “I am pretty sure he crashed right in here”, he was 5 yards away.