Depends on your recoil aversion and, closely related, your appetite for carrying heavier rigs.
I've killed a lot of game with various 300 mags. 338's, too. There's no doubt that a big 30 cal will put game down near and far. I watched a guy put down a huge bull elk this fall at 700 yds with a 300 PRC.
But they also recoil more than most care for, which negatively affects the amount most are willing practice. This is not a good combination for building long range proficiency. Heavy recoil can be overcome, but it takes more rounds downrange than many are willing to endure. Certainly, heavier rigs will recoil less, but there's, of course, trade offs.
The 7 PRC might be a good alternative that won't really cost effective range, yet will have less recoil than the 300. Likewise with a 6.5 PRC, which recoils substantially less than 7mm mags. All have good loads readily available for decent prices.
Basically comes down to knowing yourself and what you're able and willing to master as far as recoil and carry around for weight.