Since 2005, with the single exceptions of 2020 and 21, I have been going either to RSA or to Namibia on a cull hunt every year, killing anywhere from 25 animals on a year that really nasty weather caught on us, up to 98. I have done all these trips accompanied by RC, my hunting buddy, and witnessed his kills on a similar amount of game as me.
To put it short, having taken different calibers from the 22-250 up to the 300 Wby., my very favourite are the said 22-250 with 77gr TMKs, the 6XC with 105gr VLDs, and the 6x5x57R with 130gr VLDs, in that order. I keep on testing things so these might change in the future.
Put a 2-3 or 4" hole in the lungs of the toughest oryx, blue wildebeest, zebra or whatever with one of the little guys, and all the theories about the African animals being magically tougher that the rest of the world´s will fall to pieces.
Someone mentioned he had killed 10 oryx, and being that a great experience, let me say I have shot 20, this year, just to put things in perspective.
And no, you should not take a PH judgement on these things as the word of God, at least not any PH´s, since many of them are simply not interested and pay no attention to these things at least at the level some of us do.
Just my 2 cents.