There were 6 arrows that grouped well in bareshaft testing, I didn't mess with those nocks but it would've been interesting to see if turning the nock would've caused them to hit outside the group. I've never tried an arrow sold with less than .003 straightness but would expect a higher percentage of .001 match grade arrows to hit in the group without turning nocks; pure speculation though.
That said, the one arrow that was a cull was an obvious outlier; it wouldn't hit in the group no matter what and I recall it was always high right about 3-4" at 25 yards and it was shot randomly about 40 times. I really have no data to base this opinion on but I would think the number of arrows culled or needing nocks turned would be relative to the grade of the arrows.
I did this nock tuning in a somewhat double blind fashion with three arrows in each round and had the arrows numbered. Each arrow was shot at least three times, if it hit in the group it got fletched, if it didn't I'd turn the nock 1/4 turn and throw it back into the untested pile until only the cull was left.
Hope this helps. I like the idea of fletching first then nock tuning but I run three fletch and a different color cock vane. Ultimately, I probably can't shoot the difference but am really glad I took the time doing it as I did and am glad I didn't have the culled arrow spun up with a broadhead in my quiver.
Added to clarify: each bareshaft was shot at least 3 times regardless of nock orientation. If an arrow hit in the group three times it was fletched, if not, the nock was turned and it got three more chances to hit in the group, rinse and repeat if it still didn't.