I dont have experience with this rail in particular, but I do with the area 419 rail they make for the cz452/5/7. That's a 22 rimfire rail that also uses set-screws to tighten onto a groove in the action. I have had the one on my 22 loosen several times--it MUST get threadlocker on it, as lots of vibration cycles always seems to loosen it. I also see the one you linked specifies nothing with big recoil--seems obvious they are either worried about loosening, or worried about it slipping under hard recoil. Based on that alone, and how that aligns with my experience with a somewhat similar rail, I'd say it depends a lot on what you are shooting and how diligent you are in installation, and what the consequences of a slip are. If it's a legit concern for you, I would for sure prefer to get a real pic rail added via a gunsmith drilling/tapping your action for larger screws and maybe even using rocksett or welding it on, etc. But it's certainly a non-intrusive solution for a lower-recoiling cartridge, and it isnt so expensive that it isnt worth a shot. I'd try it and let everyone know how it goes.
From the instructions:
(We understand that this is the widely published torque spec for an 8-32 screw in general. We have gone as high as 30inch pounds of torque with no problems)
Test firing sequence. Fire 12 rounds, with the firearm unloaded, check all screws for proper tightness. Fire 12 roundsand repeat the screw check. After the first 24 rounds check your screws for tightness every 50 rounds for 150 rounds,your mount should be seated.
1) sounds like you might be able to go a little higher
2) sounds like loosening is a legit concern.