Just be sure to file down the front sight ... (leaving out the rest of the joke)
Seriously though, penetration is very important. Newer bullets like the Extreme Penetrators Monolithics are recommended by Underwood, but have the side benefit of being much lighter with less kick than the more traditional hard cast bullets.
My thought is that no matter if I'm carrying a .357, 10, or .44, I'm going to carry those rounds. It's more important to have a gun that you can shoot accurately with follow up shots than having one big round. I think most people can do follow up shots easier with a semiautomatic, but revolvers are great if you are someone who spent time learning how to shoot them accurately in double action. It's hard to beat a Glock 10mm for most people.
As someone pointed out even big bears have been killed by a lot of different calibers, but don't forget the bear spray.