I don’t have the best definitive answer, but faced with a similar situation recently, this is what we decided to do: in service of helping a friend prepare for a UT muzzleloader hunt, we’ve outfitted a CVA LRX .50cal with an above average Burris 4.5-14x50 - because we had one, and neither of us are convinced of a need for one of the “Big 3” named scopes on a muzzleloader. Both of us are new to muzzleloading, and as of this response, still have not shot this new unit. Our theory however is, if this new “long range” muzzleloading equipment lives up to the hype, then, if we do our due diligence in developing loads for both pellets and loose, and lots of fairly extensive documentation of speeds attainable via working w/a chrony…..then theoretically we should be able to come up with a load(s) that should repeatably correspond to the holdover hashmarks on the Burris reticle(?) Although not designed for muzzleloader trajectories, we’re hoping to get it right, since the UT regs. have no scope power restrictions. If our theory and load trials don’t prove adequate and repeatable, then I guess it’s back to the drawing board. Hope to have an answer by this weekend. This rationale may or may not prove helpful to you; either way, best of luck w/your decision!