I drive a lot for hunting, usually 10+ trips of 10 hours, and 2-4 trips that are 24+ hours annually plus a handful of family trips where I'm the main driver. I usually drive it solo or with my son (10, he can't drive). When I was younger, it was no big deal, just jump in the truck and roll, pee and eat when I get fuel and those are the only stops. The older I've gotten the harder that is. I'll pull over and take a nap now, usually 30 minutes - 1 hour. Loud music, caffeine, windows down, etc all works to a certain extent, but there's always a point where I just need to pull over if I'm rolling solo or with my son. Not worth serious injury or dying to get there an hour earlier.