I agree with everyone here. Load until the case no longer functions how it should...but some things can sneak up on you. I notice that it becomes harder to set back the shoulder while resizing the brass after 3 or 4 reloads. It's like the metal isn't as flexible anymore (which it isn't). My resizing die is set up to set back the shoulder 3-4 thousandths (reloading for an AR), but it rebounds back to only 1-2 thousandths...sometimes less. This has caused feeding issues and precision inconsistencies. I can still get the brass set to where I need it to be, but it requires me adjusting my resizing die. I accidently mixed up some older brass with newer brass, and it became a huge pain in the butt. I just got myself an annealer. While I am still very new to annealing, it has seemed to fix my problem. As long as I anneal every 2 reloads, I no longer run into inconsistencies with my resizing die. Right now I'm on 7-8 reloads on my factory Hornady 6mm ARC brass and they are still working great...especially now with the annealer.