20 hours is about my limit, going solo at my age. Distance is no more than 2000 miles.
that includes an overnight in the vehicle, at rest area.
I've done both, fly & drive. Each has its merits and downsides. But retired now so driving is 1st choice....got the time.
One thing I really like about being able to drive. I can kill last day, last hour. Then have couple days to pack out, process as butcher/wrap myself, and then drive home with everything.
Few years ago dropped a bull on 2nd to last day (a Saturday). It was all I could do solo to pack out, process, pack gear/luggage and make flight home on a Monday morning. Only to fly back 3 weeks later and pick up frozen elk from friends freezer. Checked 3 coolers to get it flown home. MVP Million Miler so limit was 3 checked bags & carryon-overhead and 1 personal item.