I asked my doc about Diamox at my physical a couple weeks ago in prep for our trip in a month. He prescribed it to me and also recommended not to over hydrate and to increase carb intake while at altitude. He said over hydrating can have just as much effect on AS as getting dehydrated.
I don't see over hydration being a thing here in Colorado, I think most peoples issues with perceived altitude sickness are actually dehydration. A lot of people fly in for their ski vacation and party it up the night they arrive at their condo in the mtns and then spend the next couple days on the couch or in bed recovering from altitude sickness. Colorado may be green in the mountains but Colorado is in fact a desert environment, drinking water cannot be understated.
Even living here, I start drinking water, gatorade or whatever your preferred means of hydration are at least an hour before I begin to engage in said activity.