Absolutely, If you hit them perfect, everything works. Mechs, skeet loads, everything. I killed a pile of critters in Africa 10 years ago, shooting 425 grains, from a pit blind, perfectly set up, 18 yards....yup. Target practice.
but what...about....this IF thing?
The hunting situation is incredibly dynamic, including this thing called blood pressure, adrenaline, and general FREAKING OUT with a bull screaming at you or the biggest deer you've ever seen. The target animal is an incrediby dynamic combination of soft, hard, bone, bone angles, multiple possible bone structures, maybe mud, hair, etc. A rutting bull lacks hygiene.
I get a pile of private correspondence starting with "bonked the shoulder on the biggest deer of my life and I am looking to at least increase the odds of that not happening". Honest people who really want to punch their tag. No one they know offers a solution except "you can't break bones with an arrow and you need to shoot better". Truly kind of sad.
Because - its old fashioned to blame ourselves......but I am old fashioned so here we go.
You might pull a shot, or a combination of YOU screwing up the shot and: the animal might step, jump, roll or just stand there like a 3-D target and you still pulled the shot. You may shoot perfectly and the animal may: step, jump, drop, roll, or stand there like a 3-D target.
You don't know.
From a treestand the most common thing is a very accurately RELEASED arrow and the deer dropping and rolling. This pulls the shoulder blade down, heavier bone is now in motion, behind the shoulder is ribs or spine or both, the animal and its annoying bones.....are moving in a lateral direction, compare to the direction of your arrow.
It's just a consideration - not throwing flames here, you don't need to jump off the bridge and shoot 700 grains.
The 150 grain head and a change to a COC will help your odds, adding 100 grain inserts behind that 150 grain head....oh man, you're talking exponential gains.
Rule #1 - skeet or adult arros. Make sure your arrows are flying awesome.