The “starting from” price listed on Ford pickups is a total joke. Go play around with the truck builder on Ford’s website. I’m not up to speed with every option and package, but if you start with a base model in both series and then add a crew cab, 4x4, and the trailer tow package you will see that the price jacks up faster on a 250 than a 150.
Not to mention, my ‘21 3.5EB creates more HP and Torque than the 7.3 gasser 250s and gets double the MPG when towing. I know that’s not everything, but adding the 6.7 diesel to a 250 for more power will tack on another $8-9k right out of the gate. The Trailer tow package that ups the weight to 11,600 lbs, and adds the brake controller and pro backup assist runs about $1,500 to add. Ford does some real janky stuff with what you can and can’t add to the trucks based off the trim level, engine, and packages you want though.
I paid $47k total for my ‘21 F-150 XLT with 12k miles on it at purchase. Sticker price on a new one at that time was $62k. It has the 3.5EB, Trailer Tow package, extended fuel tank, and has the XLT high interior with the heated seats, bigger screen, yadda yadda. No way I was getting a similar priced 250 with the same options. My 150 is better for mpg, off-roading, general maneuverability, and more than tows my ATVs or SXS with extra stuff in the bed and trailer.