Just my .02 but for a one gun setup id go 25 or 6.5 creed. Pretty good at everything (power, range, recoil, barrel life etc). For a two gun setup id go with a 223 or probably a 22 arc and a 6.5 prc (great recoil and barrel life out of the 22 cal and the 6.5 prc has decent recoil and barrel life for a very capable setup for anything.
Personally I run a 300 RUM, 6.5 prc, 6.5 creed, and 223. The RUMs no fun to shoot, but great to hunt with. The prc’s fine to shoot and hunt with, the 223 and creed are great to shoot and ok to hunt with.