I switched from MOA to MRAD pretty recently (after last hunting season), and here's my takeaway so far...
1.7 mil at 450 is easier to remember than 5.75 MOA. I have AB ballistic solver in my RF, but if I'm on a different profile it's way easier to shoot with just a range and not a solution. I have not even really worked on quick drop process very much yet, but I can do it in my head if I have a little bit of time.
Wind is way way easier and faster. I don't even reference the wind in my solver for most shots anymore since gun number is so easy.
Making corrections with others using a spotter/binos is no factor. Spotter is estimating a measurement in inches, and shooter is not converting that to angular whether using MOA or MRAD. Shooter estimates what looks like that number of inches and sends next round regardless of reticle.
Two challenges that I've found are as follows: shooter and spotter both have reticles, one MOA and one MRAD. Spotter has fairly precise correction to give, shooter can't utilize it effectively. Rare, but not never. Falls back to offering an estimated linear correction same as if spotter has no reticle. Obviously this challenge cuts both ways, and sticking with MOA only eliminates it if you never shoot with mil guys. If it's a mix you're going to be speaking different languages at some point regardless.
Second, milling a target size is still less intuitive to me with MRAD than with MOA. I've found shooting rocks to be a little rougher determining target size, though I've simply adjusted my frame of reference to largely make this irrelevant. A .5 mil target is approx 1.5 MOA and is a good "small-ish" rock to try to hit. The math is easy enough from there if I care to do it... At 600 yards, a .5 mil rock is going to be 10" give or take.
Zeroing is a tiny bit less intuitive as well since the targets I use have 1" grids, but that is such a minor inconvenience that I consider it to be no factor in the decision process. Center of group is easier to determine on paper rather than through the optic for me, so I have to do a little math. ⅓ of an inch per click, and round up since it's actually .36 is easy enough and close enough to get me there just as fast as .25" per click.
At this point, my only regret in the switch is not doing it sooner. The benefits have far outweighed the challenges for me.