I would look at the Stone Glacier Sky 5900 or one of their bigger packs. I love my Stone Glacier Approach for day hunting and I am buying the 5900 bag this year for 2-5 night hunts. I have the Krux frame and it works really well for me. The new frames might be better. Kifaru obviously has a number of packs that would work well for your needs and I would also look at the Exo 3500/5500.
I have seen the Mystery Ranch packs and they seem well made and laid out. I wouldn't have a problem hunting with a Metcalf. I have never seen the SO packs, so I can't comment.