I really like the 180 Accubond. It's worked for me.
The only concern I have with the TSX and ETip out of the '06 is that at long range you'll get a lot less expansion. We pulled one from a moose a few years ago that could have been wiped off and fired again, and that was out of a .300WM> 500yds.
Impact speed at 500 is down around 1900fps. That's getting really marginal with any of the mono metal bullets.
I agree, which is why I shoot lighter ttsx for more velocity. They retain higher weight so a 165 will penetrate like a 180 or 200.
I shot a whitetail at 200+ this year with a 180ttsx with good expansion.
I'll admit I'm a little mystified by how the mono metals work but they do- heck, a friend of mine walked a 100gr TSX clean though both shoulders of a bull elk this year from a .257Wby. at 250yds. I'll agree that light for caliber and higher speeds seem to make these work better than conventional wisdom says they should.