Mind you, I don't actually do this most of the time, though I do something close. Most of the time I shoot a "velocity ladder" at 100 yards when I'm first trying out a new bullet-powder combination. 1-2 shots at each powder charge, .5 grain increments apart, up to .5 grains over book max, shot over a chronograph. But I'm not looking for "nodes." I'm doing it mostly to record the velocity spread for my own OCD and to make sure I don't see pressure signs at or slightly after book max. I shoot them all at the same POA. If those 10 shots are at or under 1.5 inches, it'll be "good enough" when everything is the same powder charge. At 100 yards, this happens a lot even with muzzle velocities 100-200 fps apart. Then I'll load 10 or 20 at the powder charge that gets me my target velocity (under book max) and validate. If not, or if I can't get my target velocity before pressure signs or book max, then I'll change powder or bullet and try again.
This is a really good thread and will likely help a lot of reloaders who a struggling with load development efficiency, mixed in with a bit of reloading enjoyment of fine tuning and tinkering.
When I develop a load I'm primarily seeking to obtain near maximum velocity without risk of over-pressure. Yet, I am still mixing in a bit a OCD and enjoyment of dialing the final chosen load. To obtain my goal of near max velocity without overpressure risk, I basically do the same as Okie_Poke.
I research load books and online discussion on the caliber, powder, and bullet combination and then load 3 rounds each at 1 grain under max, and 0 grains under max (6 rounds total). I shoot over a chronograph, so I usually find that 1 grain under max shoots just under my desired velocity, and the max load shoots a bit over my desired velocity.
If there are no pressure signs in either of these two loads, then my OCD kicks in and I will then will load 3 more of each in 0.2gr increments to further tune my velocity. For example if I'm fine tuning between 71.0 gr and 72.0gr, then I will load 3 each at 71.2, 71.5. 71.7 (9 rounds).
This method usually requires shooting a total of 15 rounds to choose a load.
When I choose my final load, I will shoot 20 rounds to verify acceptable velocity, accuracy, ES, SD.
OnTarget TDS is a great tool for analyzing groups. Look into using it or something similar.
Finally, it has been well stated previously that accuracy or velocity nodes do not exist if you are shooting large enough groups to establish a significant population of data points.
. Yep. I wish we could have suppressors. Had a moment the other day and cracked one off without ear pro out my shop window. 
