Since you specifically mentioned PA I thought I'd try to help.
The Pennsylvania Regs are pretty strict, and I do know of a couple pals that got in trouble when they brought back their heads that still had the eyes and some brain material in them. Best to do one of the following:
1. cut off and clean just the skull cap
2. fully boil and clean the skull "euro style"
3. have your taxidermy done out there and shipped back
From the PA Game Commission Website
PGC CWD page
What if I'm hunting outside Pennsylvania?
Pennsylvanians who harvest deer, elk, mule deer or moose out-of-state likely can’t bring them home without first removing the carcass parts with the highest risk of transmitting CWD. As of Sept. 2019, there are 25 states and three Canadian provinces from which high-risk cervid parts cannot be imported into Pennsylvania. Regulations prohibit the importation of any high-risk parts or materials from cervids harvested, taken, or killed within
areas where CWD has been detected. The
Chronic Wasting Disease AllianceOpens In A New Window is also a reliable online resource. Hunters who are successful in those states and provinces from which the importation of high-risk parts into Pennsylvania is banned are allowed to import meat from any deer, elk, moose, mule deer or caribou, so long as the backbone is not present. Successful hunters also are allowed to bring back cleaned skull plates with attached antlers, if no visible brain or spinal cord tissue is present; tanned hide or raw hide with no visible brain or spinal cord tissue present; capes, if no visible brain or spinal cord tissue is present; upper canine teeth, if no root structure or other soft tissue is present; and finished taxidermy mounts. Hunters who harvest cervids in a state or province where CWD is known to exist also should follow instructions from that state's wildlife agency on how and where to submit the appropriate samples to have their animal tested. If, after returning to Pennsylvania, a hunter is notified that his or her harvest tested positive for CWD, the hunter is encouraged to immediately contact the Game Commission region office that serves the county in which they reside for disposal recommendations and assistance.
Best of luck on your hunt! I'm headed to Colorado myself in another 32 days!