Get a Garmin InReach, give your spouse or a friend an email with a screenshot with markings on it of what your plan will be. Times and Dates of when you will enter and expect to exit by. Do NOT vary from the plan! Not by much anyway. That plan will be what saves you.
Get your Doctor to give you an Rx for an opiate pain med to carry in your pack!
If they give ya grief, and they will now since they are making it harder for regular responsible folks to acquire meds these days (Grr!) ask for just Tylenol #3's, which have Codeine. Explain the purpose you need it for, that it's a just in case type of thing, or like in my case that you have certain old injuries that also sometimes bark up real bad if the hike-in is unusually long or steep. They will give you an Rx for no more than 15 count.
I had a slip-and-fall while crossing a creek on a hunt and shattered my wrist out there. Had to hike back and then drive my truck all the way home. (Figured they'd med me to re-set it, didn't want Mama and the boy held hostage waiting around for me to be off meds so I could then drive my vehicle back home, so decided to just hurry up and drive it on home directly) Would have sucked a bit less with something more industrial strength to take it down a notch. I now have a plate and 13 screws in my wrist from that day.
Always carry Imodium, and Acid-blockers (Tagamet, etc). Always carry eye-drops to help with allergy type reactions to the pollens and so forth. Naphcon-A seems to work well without burning like some of them do. Don't forget to use that 70+spf unscented baby sunscreen on tip of nose and edges of ears.
Be extra cautious about NOT traversing anything sketchy. Don't jump down off stuff. Always think safely versus saving time. Don't tempt fate!
Have an extra first layer shirt that you will wear while doing your hike-in. That one will get sweatied up. Maybe a mile to 1000yds back from your spot, you change-out that sweaty shirt and possibly leave it sprawled out over a chaparral bush near where you'll come back and setup your tent later.
Pre-Hike-in several bottled gallons of water into your spot if you can. Can not tell you how glorious it is to have extra water on hand!
On pre-trips handle clearing out your spots and possibly building blinds out of natural materials.
At your car have extra regular water to be used for giving yourself a sponge-bath when you arrive back to your vehicle. Along with a change of clothes you specifically pick for doing the drive back home so they are more comfortable. Even when it's sorta cold, you'd be surprised how good having that sponge bath first feels towards your comfort returning home, so you're not all sweaty and itchy for hours on the drive home.
And for me, I always leave an energy/caffeinated drink back at the vehicle so that if I feel very spent it'll make sure I don't have scary bouts of feeling sleepy at the wheel while driving down out of there on mountain roads. And if you're unsure at all about your tiredness levels, set an alarm for 20mins and nap a bit. Helps a ton. Driving exhausted is no joke!
Oh! And DO NOT forget to have a Tow-Strap in your car! Along with a can of Fix-A-Flat spray and mini air-compressor, etc.
MAKE SURE you pack most of the stuff into your vehicle the night before! Or at least get it all ready to just grab and go! Don't trust that sleepy you at 2am-2:30am will remember all the things you need to or wanted to bring on your trip! Sucks real bad to forget to pack vital things... like boots! #FacePalm