There is no animal that is tougher than any other.

[roadrunner]

Some (maybe most) people, that have hunted them anyway, will say that oryx in NM are the toughest animal in North America, a transplant going on 50 years ago now.

I haven't found them to be any more difficult to put down than a cow elk. A well placed bullet of proper design through both lungs will out them down every time.

Anywhere else, on the other hand, can be quite a different story.

 

[Mojave]

Some (maybe most) people, that have hunted them anyway, will say that oryx in NM are the toughest animal in North America, a transplant going on 50 years ago now.

I haven't found them to be any more difficult to put down than a cow elk. A well placed bullet of proper design through both lungs will out them down every time.

Anywhere else, on the other hand, can be quite a different story.

I have killed 3 oryx in Namibia. They have confusing anatomy inside. A good shot will kill them, a bad shot and they will run a million miles.

Zebras are the toughest thing I have ever shot in Africa. Lunged one and he went 500 yards uphill.

Pronghorn to me are interesting. You can shoot one badly and they can run forever. Then absorb more "better shots" until you actually get things in the right spot or the tip over from dropping gallons of blood.

 

[roadrunner]

Oryx vitals tend to be caged in pretty tight behind the forward portion of the ribcage and front shoulder.

You want a bullet that holds together more rather than one that explodes, hypothetically speaking anyway.

 

[Reddish]

Armadillos have required the most shots to subdue for me.

 

[DangerRanger]

From my experience with horses they want to die 24/7