Between 2007 and 2011, I used the .243 a lot, exclusively with Sierra's 85-grain HPBT. Between deer, antelope, coyotes, and pigs, I think only one animal ever took a step after impact. That was a giant California boar with the thickest shield I've seen. The bullet penetrated the shield and blew up one lung. No clue how far he'd have gone, as my buddy headshot him a second after that.
Today, I'd rock the 95-grain Ballistic Tip or 95-grain TMK, but there a ton of good options for .243 and 6mm Creed class cartridges.