There is a first time for everything. I have done it several times. Very rewarding and confidence building.
Try to get there early and do as much scouting as possible. Be reasonable on how deep you go for your first time. Have a communication plan. Make sure two people know where you are going. Watch the weather for that big snow. Relax and enjoy the solitude, the kill is not the success.
It's a long drive alone so allow time for it. Be specific on gear, you have been there before. You know what YOU need and what you can do without.
You mentioned that you have hunted there before so you have a leg up. Maybe have one of the guys that has been with you before be one of your contacts just in case. He will know where to begin.
When you get one down, have a plan to get it out and take care of the meat. If elk, take a reasonable load as the base line the first trip out. You don't want to be so stoved up that the next trip is agony.
The thing about solo is you are the only one who knows what it was like. No witness, no one to share the story that can truly relate. It's a whole different experience. A group is fun and has that shared quality, solo is more introspective and thought provoking. You are more tuned in by necessity. Many folks fear being alone, but once done it will change you.
Safety is the only real concern.
I have a friend from Michigan that lives in Colorado now. He lives to hunt. He was from the thumb area. Around Rifle Co. now. What general area do you plan to hunt? Might be a connection.
If you go, I would like to hear your thoughts on your experience.
Nick